Lung-RADS Versus Pan-Canadian Early Detection of Lung Cancer Study Screening for Patients at High Risk of Lung Cancer

Key Messages

• Evidence of variable quality from 6 diagnostic test accuracy studies indicates that the Pan-Canadian Early Detection of Lung Cancer (PanCan) model may perform better at determining which lung nodules identified by low-dose CT are cancerous compared to the Lung Imaging Reporting and Data System. However, evidence from 3 other studies, also of variable quality, suggests that the risk calculators have similar diagnostic test accuracy.
• No studies were identified that compared the clinical utility of PanCan versus the Lung Imaging Reporting and Data System.
• Results from 2 economic evaluations were inconsistent about the cost-effectiveness of the 2 lung cancer risk models. However, each study applied the models to different types of lung nodules.
• One evidence-based guideline recommended that PanCan be used in the UK for initial risk assessment and for the management of lung nodules.