Vol. 1 No. 11 (2021)
Health Technology Reviews

Computed Tomography-Derived Fractional Flow Reserve for the Diagnosis of Coronary Artery Disease

Published November 11, 2021

Key Messages

  • Computed tomography-derived fractional flow reserve (CT-FFR) may predict coronary artery disease or flow-limiting stenosis in adult patients with stable chest pain better than coronary CT angiography alone, based on the relevant studies in 2 systematic reviews.
  • CT-FFR is associated with a decreased need for invasive coronary angiography and revascularization in adult patients with stable chest pain, based on findings from 1 systematic review.
  • In the US settings, CT-FFR was dominant (i.e., less costly and more effective) compared to stress testing for the evaluation of low-risk stable chest pain, based on findings from 1 cost-effectiveness study.