Lisocabtagene Maraleucel (Breyanzi)

Key Messages

• CDA-AMC recommends that Breyanzi be reimbursed by public drug plans for the treatment of adult patients with diffuse large B-cell lymphoma (DLBCL) not otherwise specified (NOS), primary mediastinal large B-cell lymphoma (PMBCL), high-grade B-cell lymphoma (HGBCL), and DLBCL arising from follicular lymphoma, who have disease that is refractory to first-line chemoimmunotherapy or who experience relapse within 12 months of first-line chemoimmunotherapy, and who are candidates for autologous hematopoietic stem cell transplant (HSCT), if certain conditions are met.
• Breyanzi should only be covered to treat adults with DLBCL not otherwise specified, PMBCL, HGBCL, or DLBCL arising from follicular lymphoma who do not experience a response to first-line therapy or who experience relapse within 12 months of first-line therapy; who are eligible for autologous HSCT; and who are in relatively good health (as measured by performance status).
• Breyanzi should only be reimbursed for patients who have not yet been treated with chimeric antigen receptor (CAR) T-cell therapy, if it is prescribed and administered by clinicians with expertise in lymphomas and CAR T-cell therapy in a hospital setting with adequate resources, and if the cost of Breyanzi is not more than that of axicabtagene ciloleucel (axi-cel). It must also be feasible to administer Breyanzi.