Vol. 2 No. 4 (2022)
Reimbursement Recommendations

Fostamatinib (Tavalisse)

Published April 22, 2022

Key Messages

  • CADTH recommends that Tavalisse not be reimbursed by public drug plans for the treatment of thrombocytopenia in adults with chronic immune thrombocytopenia (ITP).
  • Evidence from 2 clinical trials showed that after 24 weeks of treatment, Tavalisse was only modestly effective in increasing the likelihood of achieving a sustained platelet count greater than 50,000/µL; in addition, treatment with Tavalisse did not significantly reduce bleeding occurrence or severity compared to placebo, and whether treatment with Tavalisse improves health-related quality of life (HRQoL) is not known.
  • Patients identified a need for treatments that can reduce symptoms and bleeding events and improve other quality of life measures; there was not enough evidence to show that Tavalisse would meet this need.