Published September 16, 2021
CADTH recommends that Trikafta be reimbursed by public drug plans for the treatment of cystic fibrosis (CF) in patients aged 12 years and older who have at least 1 F508del mutation in the CFTR gene if certain conditions are met.
Trikafta should be reimbursed for patients who have a percent predicted forced expiratory volume in 1 second (ppFEV1) of 90% or less at the onset of Trikafta treatment.
At least 1 of the following must be demonstrated after 6 months of treatment with Trikafta: an increase of at least 5% in ppFEV1, a decrease in the number of pulmonary exacerbations or number of days that antibiotics needed to be taken for pulmonary exacerbations, a decrease in CF-related hospitalizations, no decline in BMI, or an improvement of at least 4 points in the CFQ-R respiratory domain scale. The price of Trikafta must be lowered to be cost-effective and affordable.