Vol. 1 No. 6 (2021)
Reimbursement Recommendations

Luspatercept (Reblozyl)

Published June 24, 2021

Key Messages

  • Clinical evidence suggests that Reblozyl should be reimbursed to treat anemia associated with beta-thalassemia in adults who require blood transfusions on a regular basis if the cost is reduced.
  • Reblozyl is not cost-effective at the submitted price and would require a price reduction of at least 85% to be cost-effective at a $50,000 per quality-adjusted life-year (QALY) threshold.
  • Reblozyl is expected to increase budgets by at least $33,415,422 over 3 years.
  • If the price of Reblozyl is not reduced to a point that is affordable to public payers, this could delay access to the only treatment shown to reduce transfusion burden.