Vol. 5 No. 5 (2025)
Reimbursement Reviews

Amivantamab (Rybrevant)

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Published May 22, 2025

Key Messages

  • Reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
  • The assessments inform nonbinding recommendations that help guide the reimbursement decisions of Canada’s federal, provincial, and territorial governments, with the exception of Quebec.
  • This review assesses amivantamab (Rybrevant) 350 mg/7 mL (50 mg/mL) single-use vial.
  • Indication: In combination with carboplatin and pemetrexed for the first-line treatment of adult patients with locally advanced (not amenable to curative therapy) or metastatic non–small cell lung cancer with activating epidermal growth factor receptor exon 20 insertion mutations.