Lutetium Oxodotreotide (Lutathera)

Key Messages

• CADTH recommends that Lutathera should be reimbursed by public drug plans for the treatment of unresectable or metastatic, well-differentiated, somatostatin receptor (SSR)–positive pancreatic neuroendocrine tumours (pNETs) in adults whose disease has progressed after treatment with a somatostatin analogue (SSA), unless there is a contraindication or intolerance, if certain conditions are met.
• Lutathera should only be covered to treat adult patients with unresectable or metastatic, well-differentiated, SSR-positive pNETs whose disease has progressed after treatment with a SSA, unless they could not receive an SSA.
• Lutathera should only be reimbursed if it is prescribed by clinicians who are experts in radiopharmaceuticals, patients are treated in specialized centres with the infrastructure to safely use radiopharmaceuticals, and the cost of Lutathera is reduced.