Artificial Intelligence–Enhanced Rapid Response Electroencephalography for the Identification of Nonconvulsive Seizure

Key Messages

What Is the Issue?

• A nonconvulsive seizure is seizure activity defined by an altered mental status, subtle limb twitches, or changes in speech. They are more difficult to identify than convulsive seizures as they do not have the distinctive motor activity associated with convulsive seizures.
• Patients in emergency departments (EDs) and intensive care units (ICUs) with suspected nonconvulsive seizures must be monitored with an electroencephalogram (EEG) to confirm diagnosis. Rapid detection of nonconvulsive seizures is crucial — a delay in treatment risks brain injury.
• There can be significant delays in accessing conventional EEG monitors and treatment because of limited supply in critical care settings, such as EDs and ICUs.

What Is the Technology?

• The Ceribell system is a rapid response point-of-care EEG designed for use in the ED and ICU to help identify patients who are having nonconvulsive seizures.
• The portable device has an artificial intelligence (AI) algorithm, Claritγ, that monitors seizure activity within a 5-minute interval to determine the seizure burden during that time frame. The device alerts a bedside care provider if seizure activity occurs. This information can guide physicians’ treatment plans.

What Is the Potential Impact?

• Within the ED and ICU, Ceribell could be used to increase access to EEG, allowing for faster detection of nonconvulsive seizures.
• Conventional EEG monitors are expensive and usually require a trained specialist to use and interpret findings. Most hospitals have limited access to conventional EEGs, which can lead to delays in treating patients with nonconvulsive seizures.
• In critical care settings, Ceribell may improve efficiency and patient flow by shortening time to diagnosis, preventing unnecessary treatment escalation, decreasing transfers to tertiary care hospitals.

What Else Do We Need to Know?

• The Ceribell system is not available in Canada as of this writing.
• The Ceribell system could improve time to treatment for patients with suspected nonconvulsive seizures due to the complexity and personnel needs of conventional EEG systems.
• Current research on the Ceribell system has mostly been retrospective with small sample sizes; therefore, the results may not be generalizable to a wider population.
• If the system is implemented in hospitals, training is required to ensure that all health care professionals in the ED or ICU know when to order the portable EEG so that the use of Ceribell is prioritized for patients with suspected nonconvulsive seizures.
• Datasets used to train AI algorithms tend to underrepresent equity-deserving groups, so implementing AI systems such as Ceribell with Clarity in health care settings could increase health care inequity for those not well represented in algorithm data.